RAWAL GROUP Chemistry

Our research focuses on organic synthesis, with an emphasis on the development of effective methods and strategies for the synthesis of complex bioactive molecules. We have synthesized several intricate targets, and in recent years, we have focused on the development of effective catalysts for highly enantioselective reactions and on the use of hydrogen bonding for catalysis of reactions.

alpha-Amino Acid

Synthesis of alpha-Amino Acid Derivatives and Peptides via Enantioselective Addition of Masked Acyl Cyanides to Imines

Cycloadditions

[2+2+2] Cycloadditions of Siloxy Alkynes with 1,2-Diazines: From Reaction Discovery to Identification of an Antiglycolytic Chemotype

Substituted Enone

Squaramide-Catalyzed Enantioselective Michael Addition of Masked Acyl Cyanides to Substituted Enones

Nazarov Cyclization

Salen Promoted Enantioselective Nazarov Cyclizations of Activated and Unactivated Dienones

Silver-Catalyzed

Silver-Catalyzed Formal Inverse Electron-Demand Diels–Alder Reaction of 1,2-Diazines and Siloxy Alkynes

Welwitindolinone

A Unified Route to the Welwitindolinone Alkaloids: Total Syntheses of (−)-N-Methylwelwitindolinone C Isothiocyanate, (−)-N-Methylwelwitindolinone C Isonitrile, and (−)-3-Hydroxy-N-methylwelwitindolinone C Isothiocyanate

palladium

Palladium-Catalyzed C3-Benzylation of Indoles

n-methylwelwit

Total Synthesis of N-Methylwelwitindolinone D Isonitrile

michael

Squaramide-Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to Nitroalkenes